Evaluating the Flavonoid-Enriched fraction of Padina tetrastromatica a brown Seaweed as a Marine Chemotherapeutic Prospect Integrated MTT Cytotoxic Profiling in A375 Melanoma Cells.

Background: As marine-derived compounds are considered a new finding in recent days, largely due to too little exploration on their source. Padina tetrastromatica a brown seaweed was picked, in which only the polysaccharide compound that has been analysed so far. Still, their instrumental analysis data disclosed the presence of secondary metabolites, whose activity in various areas is less. In this study, we have explored the anticancer properties of the flavonoid-rich fraction made from Padina tetrastromatica . Methods: Anticancer property of seaweed extract was determined through MTT assay in A375 cell line. whose results are computed based on absorbance read at a wavelength of 570 nm. Result: Significant anticancer activity was observed at 50 µg/mL in seaweed & 4.82 µg/mL in standard Cisplatin from the concentrations used in analysis from 3.12 µg/mL to 100 µg/mL. Conclusion: Based on the attained result, it is clearly indicated that the flavonoid-rich fraction of these seaweeds has promising activity as reported in standard, which can be considered for future studies with these outcomes.