Analysis of influencing factors and prognosis of depression in patients with ovarian cancer

Ovarian cancer (OC) is one of the deadliest gynecological malignancies, with rising incidence rates globally. Depression , a common mental health issue among cancer patients, has been shown to significantly impa ct quality of life, treatment adherence, and overall prognosis. However, the relationship between depression and the prognosis of ovarian cancer remains poorly understood. This study aims to explore the factors influencing depression in ovarian cancer patients and assess its impact on progression-free survival (PFS) and overall survival (OS). A total of 216 ovarian cancer patients were assessed for depressive symptoms using the Patient Health Questionnaire-9 (PHQ-9). Clinical data, including age, histological type, serum CA125 levels, and presence of ascites, were also collected. The results showed that 42.59% of the patients experienced clinically significant depression, significantly higher than the general population. Multivariate analysis revealed that age, histological type, serum CA125 levels, and ascites were independent risk factors for depression in ovarian cancer patients. Survival analysis indicated that depression was associated with worse PFS and OS. These findings suggest that depression is an important prognostic factor in ovarian cancer and highlight the need for early psychological assessment and intervention as part of the clinical management strategy to improve both psychological well-being and survival outcomes in ovarian cancer patients.