Structural characterization of copper and manganese oxide nanoparticles-doped calcium silicate (CaSiO 3 ) for synthesized via sol-gel method

Copper oxide (CuO)- and manganese oxide (MnO ₂ ) doped calcium silicate (CaSiO ₃ ) nanoparticles were synthesized by a sol-gel method. The synthesized doped nanoparticles were evaluated using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM) and energy dispersive Xrays (EDX). The bioactivity of the prepared nanoparticles was investigated after immersion in simulated body fluid (SBF) by means of inductively coupled plasma (ICP). The size and bioactivity of the prepared nanoparticles after 15 days of immersion in SBF was dependent on the ion concentrations. Furthermore, biocompatibility and antibacterial assays demonstrated that the synthesized microstructures exhibited favorable performance against both Gram-positive and Gram-negative bacterial strains. Based on the obtained results, these nanoparticles, with their promising biocompatibility and antibacterial activity, hold potential for application in cancer therapy. Finally, the cellular test was carried out, the results of which demonstrated non-cytotoxicity of the samples towards MDA-MB-231 Cells.