Plasma fibrinogen level and its association with type 2 diabetes: A Comparative cross-sectional study

Background Diabetes remains a major public health concern in the world amongst non-communicable diseases. It is commonly diagnosed by glycemic level, using various glucose-measuring methods, and the condition of the specimen. In addition, other biochemical markers provide valuable insights into disease progression and complications. Fibrinogen, in particular, serves as an indicator of mild inflammation and atherosclerotic risk. Numerous studies have demonstrated that hemostatic factors, especially elevated fibrinogen levels, may contribute to the development of atherosclerosis and its related complications. These studies also report that fibrinogen concentrations tend to be higher in individuals with diabetes compared to those without the condition. Aim of the study: This study aims to investigate the relationship of fibrinogen level with type 2 diabetes, along with other biochemical parameters. Methods A comparative cross-sectional study design was employed. Results Comparison of fibrinogen level, glycated haemoglobin (HbA1c), Fasting Blood Sugar (FBS), Low-Density Lipoprotein cholesterol (LDL-c), and Total Cholesterol (TC) was significantly higher among diabetics than controls ( P  < 0.05). The fibrinogen level in microvascular complications was found to be greater than in non-complications and showed a statistically significant difference (357.6 ± 63 vs. 300.3 ± 56.8, p < 0.001) Conclusion Our results underline that fibrinogen level is found to be higher in diabetic patients compared to apparently healthy controls and revealed a positive correlation with glycated haemoglobin.