GBA1 status and sex impact on depression severity and progression in Parkinson’s Disease

  1. Pierfrancesco Mitrotti
  2. Micol Avenali
  3. Carlo Alberto Artusi
  4. Rosa De Micco
  5. Giulia Giannini
  6. Rosaria Calabrese
  7. Luca Gallo
  8. Caterina Galandra
  9. Claudia Ledda
  10. Alice Mascia
  11. Mattia Siciliano
  12. Francesco Pagliuca
  13. Luisa Sambati
  14. Valeria Sant'Elia
  15. Gianfranco Vornetti
  16. Giovanna Calandra-Buonaura
  17. Leonardo Lopiano
  18. Raffaele Lodi
  19. Alessandro Tessitore
  20. Marco Bozzali
  21. Enza Maria Valente
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Abstract

GBA1 variants increase neuropsychiatric vulnerability in Parkinson’s disease (PD). In a multicenter cohort of 234 PD patients (78 GBA-PD, 156 nonGBA-PD), we investigated how GBA1 genotype and sex impact occurrence and progression of depression. REM sleep behavior disorder predicted depression in GBA-PD, while sex, cognition, and motor complications were key predictors in nonGBA-PD. Depressive symptoms were more severe and progressed faster in GBA-PD, supporting specific monitoring of this genetic subgroup.

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  1. Version published to 10.21203/rs.3.rs-7929738/v1 on Research Square