Response of Peroxisome Proliferator-Activated Receptor Genes and Gamma- Glutamyl Transferase in Rats to High-Intensity Interval Training and Livergol

Introduction : Obesity is a major health problem and has many clinical consequences on the body's organs. Genetic factors, lifestyle, diet, and physical activity can play an effective role in weight control. Objective : This study aimed to investigate the effect of a period of intense interval training and Livergol supplementation on PPARγ and GGT in obese rats. Methodology : The statistical sample of the present study consisted of 40 male Wistar rats, which, after obesity was induced, were divided into four groups of ten: a control group, an exercise group (intensive interval training), a supplement group (Livergol supplementation), and an interval exercise and Livergol supplementation group. After completing the 8-week exercise and supplementation protocol, samples were collected from the adipose tissue and heart of the rats in the fasting state and on the day after the last exercise session, and then transferred to the reference laboratory. For statistical analysis, mean, standard deviation, Shapiro-Wilk, Levine tests, and two-way analysis of variance were used. If the results were significant, the Bonferroni test was used to determine the changes (P≤0/05). Results : The expression level ofthe PPARγ gene was lower in the control group and the Livergol supplement group, but it increased in the exercise group and the exercise + Livergol group. The activity level of GGT enzymes was higher in the control group than in the Livergol, exercise, and exercise + Livergol supplement groups. Discussion and Conclusion: According to the study's results, it can be concluded that consuming Livergol and engaging in intense interval exercise has been effective in reducing liver damage and enzyme disorders by influencing sugar and fat metabolism and increasing the expression of the PPARγ gene. Additionally, engaging in periodic and intense exercise activities, combined with the consumption of Livergol, may have a positive effect on the regulation of the GGT enzyme.