Uropathogenic Profiles and Antibiotic Resistance in Gynaecological Cases: A Microbial Surveillance Study from Northeast India

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Abstract

Background: Urinary tract infection (UTI) is one of the most common bacterial infections in women worldwide. This study explored bacterial diversity, risk factors, and MDR status of UTIs in gynecologic patients. Result A total of 896 subjects were included, of whom 278 (37.6%) were diagnosed as UTI-positive using standard microbiological protocols. Midstream clean-catch urine samples were also collected and tested for antimicrobial susceptibility as recommended by the CLSI. Significant associations were found between UTI prevalence and several risk factors, including age 18–39 years (OR: 2.14, p < 0.001), women with a previous history of UTI (OR: 7.81, p < 0.001), hypertension (OR: 2.75, p < 0.001), previous antibiotic use (OR: 2.99, p < 0.001), and during pregnancy (OR: 1.96, p < 0.001) respectively. The most prevalent pathogens were Escherichia coli (62.5%) and Klebsiella pneumoniae (16.9%). According to sensitivity patterns, Gentamicin, Ertapenem, Amikacin, and Fosfomycin for Gram-negative bacteria, and Tigecycline and Nitrofurantoin for Gram-positive pathogens, are recommended as treatment options for UTIs. Conclusion These findings emphasize the urgent need for localized antibiotic stewardship programs, routine surveillance for resistance, microbiological diagnostic support in gynecological care, and infection control measures. Responsible antibiotic use and infection control are critical strategies to prevent the spread of MDR.

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