Biomarkers for Early Detection of Kidney Injury Among Type 2 Diabetes Mellitus Patients

Chronic diabetes is relative with damage, dysfunction, and failure of several organs, especially the eyes, nerves, foot, blood vessels, kidneys, and heart. The microvascular complications of diabetes induce to renal damage known as diabetic nephropathy (DN), the most common complication of type 2 diabetes mellitus. AIM: Biomarkers For Early Detection Of Kidney Injury Among Type 2 Diabetes Mellitus Patients. METHODOLOGY: 89 patients with Type 2 DM who fulfil the inclusion and exclusion criteria RESULTS: 89 subjects with Type 2DM are enrolled in the present study to evaluate early biomarkers in the detection of kidney injury. Female predominance observed. Mean levels NGAL, Cystatin C, KIM1 and B2MG are elevated in all patients. NGAL, Cystatin C, KIM1 showed high sensitivy with low specificity but B2MG had high specificity than sensitivity. There is correlation among biomarkers and eGFR, albuminuria . CONCLUSION: The present study proves none of the biomarkers can be considered superior to the others in terms of diagnostic ability. So all these Bio markers predicts early renal involvement and also progression of illness beyond serum creatinine and urinary albumin.