The Association Between Benign Prostatic Hyperplasia in American Adult Males and Oxidative Balance Score

Purpose This study aimed to explore the relationship between benign prostatic hyperplasia (BPH) in American adult males and the oxidative balance score (OBS). Materials and methods We analyzed National Health and Nutrition Examination Survey (NHANES) data from 2001 to 2008 and 2013–2020. First, a dose-response analysis was used to assess the linear relationship between OBS and BPH, followed by a threshold effect analysis. Subsequently, logistic regression analyses (both univariate and multivariate) were performed to evaluate their associations. Stratified analyses and interaction tests were also performed. Results This study included 4,499 participants, 576 of whom had BPH. Two-segment regression model analysis indicated a nonlinear positive association between OBS and the risk of BPH. Within a specific range, each unit increase in continuous OBS values was significantly associated with an 8% higher BPH risk (OR = 1.08, 95% CI: 1.03–1.13; P < 0.05). After adjusting for covariates, individuals in the highest OBS quartile (Q4) had twice the BPH risk than individuals in the lowest quartile (Q1) (OR = 2.00, 95% CI: 1.29–3.10; P < 0.05). Notably, subgroup analyses showed no significant interactions (P > 0.05), suggesting the robustness of the main findings, which were not confounded by the other covariates. Conclusion This study suggests an association between a higher OBS and an increased risk of BPH. Thus, we recommend lifestyle modifications such as dietary changes and regular physical activity to achieve a lower OBS level for BPH prevention.