Salmonella Typhi infective endocarditis combined with multiorgan infection in an elderly woman-A case report and literature review

A 62-year-old Asian woman with multiple organ involvement due to Salmonella infection (including heart valves, bone marrow, and central nervous system) was reported. She initially presented with fever and hip pain, and blood cultures showed Salmonella infection. Her condition progressed to sepsis, septic shock, nephritis, osteomyelitis, and cerebral infarction. After admission, antibiotics were upgraded, but she later developed infective endocarditis, requiring long-term intravenous antibiotics and eventually oral Faropenem therapy. Timely blood cultures, lesion assessment, and antibiotic adjustments are crucial for managing Salmonella infections and improving outcomes. This case uniquely presents a 62-year-old Asian woman with rapid progression of Salmonella infection to multi-organ involvement including sepsis and cerebral infarction, rarely seen in adults.