Can Cyantraniliprole Affect the Cardiovascular System of Male Wistar Rats Maternally Exposed During Pregnancy and Lactation?

Chronic exposure to agrochemicals can cause a variety of adverse effects, including malformations, cardiac and neurotoxicity, and endocrine disruption. Cyantraniliprole, a systemic insecticide, modulates ryanodine receptors, potentially causing adverse effects on the physiological systems of mammals. Due to its ability to cross biological barriers, offspring of pregnant mothers are vertically exposed to this compound. Therefore, this study evaluated the cardiovascular toxicity of intrauterine and lactational exposure to two doses of cyantraniliprole in the male offspring of rats. Three groups of pregnant rats received water (control, CTR) or 1 mg/kg (CYA1) or 10 mg/kg (CYA10) of the insecticide by gavage from day 5 of gestation until weaning. Biometric parameters were assessed in dams and offspring to evaluate exposure toxicity. On postnatal days 55 and 90, male offspring were evaluated for blood pressure, heart rate, isolated aortic reactivity, body mass, visceral adipose tissue, and aortic oxidative parameters. No differences were observed between groups in maternal body mass gain during exposure and in pup birth weight. No differences were observed in mean arterial blood pressure, heart rate, body mass, visceral mass, and lipid peroxidation. Aortic contractile and relaxation responses were similar between groups at the same age. In conclusion, exposure to cyantraniliprole during early development did not have long-term adverse effects on the cardiovascular system of male offspring.