Formulation and Evaluation of Albendazole Emulgel

The current study focuses on the development and assessment of an albendazole (ABZ) emulgel to enhance the efficacy and patient compliance of topical medicine distribution. Albendazole, a broad-spectrum anthelmintic/antifungal drug, has historically had a variety of issues with oral administration, such as poor absorption and systemic side effects. To overcome these limitations, an emulgel formulation was developed that provides a controlled and extended release of albendazole via the skin. The emulgel was made by adding albendazole to a suitable oil-in-water emulsion, then gelling chemicals were added to give it a semi-solid form. The produced emulgel's physical properties, pH, rheological behavior, drug content, and in vitro drug release profile were evaluated. Stability tests were also performed on the emulgel to ascertain its longevity. In vitro drug release tests revealed a sustained release profile, indicating that the albendazole emulgel formulation can provide the medication for an extended period of time. The emulgel proved to be highly stable across a variety of storage conditions, ensuring its appropriateness for usage in therapeutic settings. The emulgel's enhanced skin penetration further demonstrated how well it works to facilitate the absorption of transdermal medications.