Nanostructured Emulsomes for the Enhanced Delivery of Cabazitaxel: A Novel Approach to Cancer Treatment and Drug Release Profiling

The current study aims to develop and elevate Cabazitaxel (CTX), which was formulated using the solvent evaporation technique and tristearin as the core solid lipid. Two formulations were created: simple emulsion(P-ES) and sterilized emulsion (SS-ES). Which is important formulation variables include the ratio of lipids to stabilizers (DSPC, CHOL & DPSE-PEG), the molar ratio between phospholipids and lipid PEG components, solid lipid content, phospholipids concentration, and organic phase and aqueous phase ratio. Distribution of mean diameter 275 ± 5.52 nm for P-ES and 195 ± 6.4 nm for SS-ES. All variants showed pH-sensitive release profiles. This was characterized by progressive and sustained drug exemptions. In particular, stable emulsions showed slower release compared to simple objects. Drug release was governed by the Fickian diffusion Mechanism following the plain model. In Summary, this study supports stabilized emulsion as a promising collection platform for stability, and perhaps other hydrophobic therapeutic active ingredients that provide stability and prolonged circulation time within the body.