Graphene-Based BioFET Sensors: An Innovative Approach for Accurate Ferritin Detection and Early Anemia Diagnosis

This study investigates the development of graphene-based field-effect transistor (GFET) sensors for the sensitive and accurate detection of biological biomarkers, with a specific focus on ferritin, a key indicator of the body’s iron reserves. The selection of graphene was based on its exceptional properties, such as high electrical conductivity and responsiveness to charge variations, making it an ideal candidate for bioelectronic applications. The BioFET sensor simulation, which incorporates the antigen–antibody interaction, demonstrated enhanced sensitivity, particularly at low ferritin concentrations. The optimization of sensor parameters, such as the graphene channel length, significantly improved device performance, offering a rapid, accurate, and cost-effective solution for early diagnostic applications, particularly in cases of iron-deficiency anemia. The study also suggests the potential integration of these technologies into portable medical devices, a move that could revolutionize remote health monitoring and significantly enhance healthcare accessibility.