Studies of some cancer biomarkers (sCD30, IL-10, and 8-OHdG), cD4 count and Viral Load in people living with HIV infection attending clinics in University of Calabar Teaching Hospital Calabar

People living with Human immunodeficiency virus (HIV) are at increased risk of developing cancers due to immune suppression, oxidative stress, and chronic inflammation. Methods: A case control study was conducted among 180 subjects, of which 100 were people living with HIV infection comprising 60 on HAART and 40 naive recruited from patents attending clinics in university of Calabar Teaching Hospital Calabar. The other were 80 age sex-matched apparently healthy HIV negative members of the public recruited as control subjects. Blood samples were collected and analyzed for sCD30, IL-10 and 8-OHdG. Others were CD4 T cell count and viral load using ELISA techniques (sCD30, IL-10 and 8-OHdG), Cyflow machine for cD4 T cell count and Real time PCR machine for viral load assay. Results: Mean values of the selected Cancer biomarkers (sCD30, IL10 and 8-OHdG) and viral load of HIV-infected subjects were significantly (P<0.05) higher when compared with the controls while of CD4 T cell count was significantly (P<0.05) lower when compared with the controls Additionally, CD4 T cell count conversely correlated with sCd30 (r=-0.678), IL-10 (r=-0. 706), 8-OHdG (r =-0.575) and VL (r=-0.704) P<0.05 Conclusions: This study highlighted the need for regular monitoring of cancer biomarkers (sCD30 IL-10 and 8-OHdG) cD4 T cell count and viral load in people living with HIV infection. This underscore the importance of immune restoration and viral suppression in reducing cancer risk among people living with HIV infection in this locality and beyond.