Non-Enzymatic Electrochemical Sensors Utilizing Dibenzothiophene

This study conclusively demonstrates that dibenzothiophene (DBT) film can be successfully employed as a non-enzymatic electrochemical sensor to detect four different analytes. Active layer is synthesized by drop-casting DBT solution on the Au electrode. The solution is prepared by dissolving 1 mg DBT in 2 ml NMP and the sensor is obtained by drying the coating. Obtained structure is structurally characterized by FTIR and SEM analyses. Current-voltage and current-concentration plots are used to characterize its sensing behaviors. Among the analytes, lactose generates the best response from the sensor, followed by fructose, while the glucose detection performance is almost the same as that of fructose. The response of the sensor to maltose is significantly lower than the other analytes. The study provides limit of detection and qualification (LOD and LOQ) values of the sensor for all four analytes. The sensor is most sensitive to lactose, as evidenced by the current density-concentration plots. The DBT-based sensor can detect lactose with LOD value of 15.40 mM and an LOQ value of 46.67 mM. These results provide strong evidence to support the possible use of DBT film-based sensors for non-enzymatic electrochemical detection of analytes as an alternative to conventional methods.