Carbon nanofiber-assisted molecularly imprinted electrochemical sensors for selective hypoxanthine detection from real samples

Read the full article See related articles

Listed in

This article is not in any list yet, why not save it to one of your lists.
Log in to save this article

Abstract

In this study, thymine functionalized carbon nanofibers (Thy@CNFs) modified molecularly imprinted electrochemical sensors has been developed by copolymerization of pyrrole-co-pyrrole-3-carboxylic acid (Py-co-PyCOOH) over the Thy@CNFs. First, Thy@CNFs was deposited on a GCE, then Py-co-PyCOOH copolymer was synthesized in the presence of hypoxanthine (HYP) by electropolymerization on a GCE modified with Thy@CNFs. Characterization studies on variations at each stage of the MIP synthesis process were investigated via electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), attenuated total reflection-Fourier transform infrared spectrophotometry (ATR-FTIR), scanning electron microscopy (SEM), and contact angle measurements. Under optimal conditions, the Thy@CNFs modified MIP-based electrochemical sensor (Thy@CNFs/MIP/GCE) demonstrated a linear response from 1 x 10 –9 to 1 x 10 –8 M, having the limit of detection (LOD) of 1.71 x 10 − 10 M. Finally, it was found that MIP-based electrochemical sensor (MECs) was successfully utilized in detecting HYP in commercial serum samples and artificial urine with satisfactory recovery rates of 99.55% and 100.17%, respectively.

Article activity feed