The role of B-Raf V600E Gene Mutation and chronic lymphocytic thyroiditis in papillary thyroid carcinoma

Background Our aim of this article was to investigate in the papillary thyroid carcinoma(PTC) patients, whether B-Raf ^V600E gene mutation and chronic lymphocytic thyroiditis(CLT) were in association with their clinicopathological characteristics and the interplay between them. Methods We had chosen 185 PTC patients who had treated in Affiliated Hospital of Qingdao University –Yantai YuHuangDing Hospital and Yantaishan Hospital during April 2023 to March 2024.We recorded gender, age, the status of B-Raf ^V600E gene mutation, CLT or not, the size of tumor, single/multifocality, family history, muscle invasion, capsular infiltration, central lymph node metastasis and clinical stage, analyzed them using logistic regression analysis by SPSS20.0. Results There were 185 patients, 138 patients were with B-Raf ^V600E gene mutation and 47 with wild type, the percentage of B-Raf ^V600E mutation was 74.59%, and the B-Raf ^V600E mutation had correlation with CLT(OR = 0.335,P = 0.009) and the size of tumor (OR = 3.751,P = 0.004). 42 patients were with CLT and 143 not, the percentage of CLT was 74.59%, and CLT had correlation with gender(OR = 3.271,P = 0.043) and B-Raf ^V600E gene mutation status (OR = 0.341,P = 0.01). Conclusions In PTC patients, B-Raf ^V600E gene mutation and CLT were in association with clinicopathological characteristics. Further investigation for the interplay between CLT and B-Raf ^V600E gene mutation in PTC needs to be done.