Comparative Ultrasound Visualization Analysis Between Ultherapy® and Ultherapy PRIME and Survey and Clinical Case Results from the Ultherapy PRIME Early Experience Program

Background: Microfocused ultrasound with visualization (MFU-V) is a non-invasive treatment for skin lifting and tightening. Ultherapy ^® (MFU-V 1.0) and Ultherapy PRIME (MFU-V 2.0) are both MFU-V devices, with the latter being recently developed with enhanced visualization technologies amongst other notable improvements. Thus, we sought to compare the ultrasound visualization components and visual noise reduction capabilities of MFU-V 1.0 and MFU-V 2.0 systems. We also sought to gain insights from clinicians with experience using both systems. Materials and Methods: A comparative analysis was conducted on the ultrasound imaging components of both systems. Screen size, pixel count, and ultrasound images taken with 3.0 mm and 4.5 mm transducers on water blocks were collected and analyzed and visual noise levels quantified. An early user experience survey was sent out to query clinicians on their experience 2 months after switching from MFU-V 1.0 to MFU-V 2.0. Results The ultrasound field of MFU-V 2.0 was 38.14% larger and its pixel density was 91.01% greater than MFU-V 1.0. Visual noise reduction in MFU-V 2.0 was significantly reduced by up to 72.02% using new transducers and up to 64.04% using used (at least 1400 lines) transducers. Nine clinicians having treated 68 patients with MFU-V 2.0 noted an average treatment time reduction of 19.7% and reported high degrees of satisfaction with the improved visualization, ergonomics, ease of use, and intuitiveness of MFU-V 2.0. Conclusion MFU-V 2.0 significantly enhances ultrasound visualization quality and reduces visual noise compared to MFU-V 1.0. Clinicians noted a reduction in average treatment time and broad system improvements with MFU-V 2.0. These improvements facilitate faster and more precise targeting during treatment potentially leading to enhanced clinical outcomes in skin lifting and tightening procedures. Level of Evidence Not applicable preclinical