Targeted Delivery of Linezolid Using Magnetic Nanoparticles to Enhance Osteomyelitis Treatment

Osteomyelitis, a challenging bone infection, is often complicated by formation of biofilms and antibiotic resistance. Traditional treatments typically involve prolonged high-dose antibiotic regimens, which can lead to various adverse effects. This research focuses on creating a targeted drug delivery system utilizing magnetic nanoparticles to improve the effectiveness of linezolid in the treatment of osteomyelitis. Magnetic nanoparticles were synthesized and functionalized with L-lysine. Subsequently, these nanoparticles were coated with chitosan and loaded with linezolid. The nanoparticles were characterized using TEM, FESEM, XRD, FTIR, and VSM. Antibacterial activity was assessed using the microdilution broth method against major osteomyelitis pathogens. The study successfully developed a novel drug delivery system based on magnetic nanoparticles. Compared to free linezolid The synthesized nanoparticles exhibited enhanced antibacterial activity. The nanoparticle structure facilitated deeper penetration of linezolid into bacterial cells, leading to a higher bactericidal effect and potentially lower required treatment doses.