Extended Drug-Resistant Salmonella Typhi Complicated by Atypical Fatal Hemophagocytic Lymphohistocytosis: A Case Report

  1. Mahnoor Baig
  2. Waqas Siddiqui
  3. Sara Soomro
  4. Rabia Shah
  5. Mariam Rashid
  6. Lubna Abbasi
  7. Muneer Sadiq
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Abstract

Hemophagocytic lympho histiocytosis is a deadly hyperinflammatory clinical response marked by excessive inflammation and tissue damage that can be secondarily triggered by infections, autoimmune and malignancies. Hemophagocytic lymph histiocytosis is usually caused by viruses and rarely by bacterial infections like Salmonella Typhi. The rising incidence of extended drug-resistant Salmonella Typhi in low-income countries like Pakistan can lead to numerous complications but hardly secondary Hemophagocytic lympho histiocytosis. We report the first case of extended drug-resistant Salmonella Typhi whose management was complicated due to Hemophagocytic lymph histiocytosis.

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  1. Version published to 10.21203/rs.3.rs-6085253/v1 on Research Square