An open-source atlas and evidence-based appraisal framework of psychiatric brain stimulation targets generated by causal network mapping

Causal network mapping is an emerging technique that can be used to derive optimal disorder/symptom-specific brain stimulation targets. This technique exploits incidental variability in brain lesion and brain stimulation locations, which creates a natural experiment in which causal inferences can be drawn between lesions or modulation of specific circuits and specific clinical outcomes. Circuits identified by causal network mapping, referred to as symptom-networks, represent candidate disorder/symptom-specific brain stimulation targets. The library of psychiatric symptom-networks has grown rapidly in recent years, creating a need for a comprehensive synthesis. The present Resource includes an open-source atlas of 12 psychiatric symptom-networks which we appraise using an established evaluative framework. These materials are designed to guide the translation of symptom-network targets and to scaffold advancements in this quickly developing field.