The Unique Relationship between Body Mass Index and Metabolic Syndrome in AIDS Patients

Introduction ‌ Metabolic syndrome (MS) poses substantial health risks for people living with HIV/AIDS (PLWHA). While body mass index (BMI) is a well-established predictor of MS in the general population, its association with MS in PLWHA remains poorly characterized, particularly in China. This study investigates the relationship between BMI and MS in Chinese AIDS patients, with emphasis on population-specific metabolic risk patterns andthreshold deviations from general population benchmarks. ‌ Methods ‌ We enrolled 482 hospitalized AIDS patients stratified by BMI categories: underweight (<18.5 kg/m², n=92), normal weight (18.5–23.9 kg/m², n=311), and overweight/obese (≥24 kg/m², n=79). MS diagnosis followed Chinese Diabetes Society (CDS) criteria. Comparative analyses of blood pressure, fasting glucose, and lipid profiles were conducted across groups. Statistical approaches included Spearman correlation for BMI-MS associations, multivariate logistic regression (adjusted for age, sex, and metabolic parameters), and ROC curve analysis to determine BMI thresholds predictive of MS. ‌ Results ‌ The overall MS prevalence was 8.92% (43/482), with striking disparities between groups: overweight/obese patients demonstrated 3.5-fold higher MS prevalence than normal-weight counterparts (24.1% vs. 6.8%, P<0.001). Metabolic derangements were disproportionately elevated in the overweight/obese group, including hypertension (31.6% vs. 12.2%) and hypertriglyceridemia (44.3% vs. 21.5%, both P<0.05). BMI showed strong positive correlations with MS diagnosis (r=0.42, P<0.001) and MS component burden (r=0.38, P<0.001). Multivariate analysis identified BMI as an independent MS predictor (adjusted OR=1.15 per unit increase, 95% CI:1.06–1.25, P<0.05). ROC analysis revealed a clinically relevant BMI cut-off of 20 kg/m² for MS prediction (AUC=0.79), substantially lower than general population thresholds. ‌ Conclusion ‌ This study identifies an accentuated BMI-MS relationship in Chinese PLWHA, with metabolic complications emerging at atypically low BMI values. The proposed BMI threshold of 20 kg/m² for MS risk stratification—25% below standard obesity criteria. Urgent adoption of HIV-specific metabolic screening is needed, prioritizing early BMI-guided interventions to reduce cardiovascular risks, even in non-obese individuals.