Investigating DNA-Interaction and Anticancer Activity of new Cu +2 complex Coordinated with Dipicolinic Acid. Experimental and Computational Studies
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A complex formulized as [Cu(dmpn) 2 (OH 2 )][Cu 2 (DPA) 4 µ-Cu(dmpn) 2 ] ( 1 ), where dmpn is 2,2 ׳ -dimethyl-1,3-diaminepropane and DPA is dipicolinic acid (H 2 dipic), was synthesized and characterized by X-ray crystallography, conductivity measurement, thermogravimetric (TG) analysis and spectroscopic methods (IR, UV-Vis). The initial in vitro cytotoxic activity of complex ( 1 ) shows promising results compared to known anticancer drugs such as cisplatin against HCT116 colon cell lines. In a recent study, the mode of the interaction between DNA and complex ( 1 ) was explored using different techniques. The experiments reveal that the mechanism of fluorescence quenching is static and the characteristic of this interaction is exothermic. The apparent binding constant (K app = 1.9×10 3 M − 1 ) shows that the interaction between the cu(II) complex and DNA is probably non-intercalation. Based on other data, it can be suggested that hydrogen bonding, and van der Waals forces play a major role in this interaction. Molecular docking simulation supports the achieved experimental results. Likewise, complex ( 1 ) shows nuclease activity in the presence of H 2 O 2 and can cleavage structure of DNA.
