Evaluation of Cardioprotective activity of Ethanolic extract of bark of Helicteres isora Linn.

This study evaluates the cardioprotective activity of the ethanolic extract of the bark of *Helicteres isora* Linn. in a laboratory model. *Helicteres isora* Linn., a medicinal plant traditionally used in various cultures for its therapeutic properties, has gained attention for its potential cardiovascular benefits. The ethanolic extract was prepared using a standard protocol and subjected to phytochemical screening, which identified the presence of flavonoids, tannins, and saponins as key phytoconstituents.In vivo experiments were conducted using a rat model subjected to isoproterenol-induced myocardial infarction. The cardioprotective effect of the extract was assessed through measurements of cardiac markers, including serum levels of creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), and aspartate aminotransferase (AST), alongside histopathological analysis of cardiac tissues.Results indicated that administration of the ethanolic extract significantly reduced the elevated levels of cardiac biomarkers compared to the control group, suggesting a protective effect against myocardial injury. Furthermore, histopathological examination revealed a marked reduction in necrosis and inflammatory cell infiltration in the cardiac tissues of the extract-treated group.The findings of this study support the cardioprotective potential of the ethanolic extract of *Helicteres isora* Linn.