The Prangos Ferulacea (Jashir) on the Candida Vulvovaginitis: A Study Protocol of clinical trial

Background: Candida vulvovaginitis is one of the most common infections among women of reproductive age, ranking as the second leading cause of visits to gynecology clinics. purpose of the study is to document the effect of Prangos Ferulacea (Jashir) on the Treatment of Candida Vulvovaginitis. Methods: This study is designed as a randomized, double-blind clinical trial that will include 112 participants divided into two groups: an intervention group and a control group. The trial will be conducted at Yasuj University of Medical Sciences. Eligible participants will be married women aged 15–45 years who present with at least two clinical symptoms (cheesy vaginal discharge and itching), a Sobel score of ≥4, and a confirmed positive Candida culture. The control group will receive clotrimazole vaginal cream, instructed to apply 5 grams intravaginally using an applicator each night for one week. The intervention group will follow the same application protocol but will use a vaginal cream formulated with Prangos Ferulacea (Jashir). Discussion: This, along with the coagulation of cellular components, results in the degradation and death of fungal cells. Conclusion: . The findings are expected to offer new insights into the potential of this herbal remedy as an alternative to azole-based antifungal treatments, paving the way for more accessible and safer therapeutic options.