Clinical Observation of Gu Ben An Tai Decoction Combined with Dydrogesterone for Early Threatened Abortion Due to Spleen and Kidney Deficiency

Introduction We aimed to observe the clinical efficacy of Gu Ben An Tai Decoction (GBATD) combined with dydrogesterone for treating threatened abortion (TA)and assess the safety of the integrated Chinese-Western medicine approach for threatened miscarriage. We also aimed to provide a reference for designing larger, confirmatory studies in the future. Methods A retrospective analysis was conducted on 66 patients with early TA due to spleen and kidney deficiency. The control group received dydrogesterone, while the observation group received treatment with GBATD and dydrogesterone. The success rate of pregnancy maintenance was compared before 12 weeks of gestation. Safety and adverse reactions of GBATD, time to symptom resolution (vaginal bleeding and/or abdominal pain), laboratory examination indicators, imaging examination indicators, and traditional Chinese medicine (TCM) syndrome scores of the two groups were also compared. High-performance liquid chromatography-mass spectrometry was used to analyze GBATD’s major component. Results After treatment, the observation group showed a more significant increase in serum levels of β-HCG, Progesterone, estradiol, and Inhibin A compared to the control group. However, the serum CA125 level, uterine artery hemodynamic indicators S/D, PI, RI values, and TCM syndrome scores for spleen and kidney deficiency decreased more significantly in the observation group than those in the control group (P < 0.05). The observation group showed higher rates of effective TCM treatment, overall effectiveness, and successful retention at 12 weeks of pregnancy than the control group did, with statistically significant differences (P < 0.05). GBATD mainly contains 17 components. Discussion GBATD combined with dydrogesterone is effective for treating early TA. It significantly reduces symptoms of spleen and kidney deficiency, lowers the miscarriage rate, and shows no obvious adverse reactions.