Effect of Autologous Dendritic Cell Administration on Changes in Renal Hemodynamics and Inflammatory Biomarkers in Diabetic Kidney Disease Patients

Purpose Chronic hyperglycemia in DKD increases proinflammatory cytokines that can cause fibrosis and affect renal hemodynamics. This study aims to evaluate the effect of autologous dendritic cell administration in DKD patients, assessed by Doppler ultrasound examination (PSV and EDV), and measurement of TGF-β and MMP-9 biomarkers. Methods This study was a one group pretest posttest with 29 DKD patients. Measurement of PSV and EDV blood flow using doppler ultrasound, as well as blood collection for TGF β and MMP 9 biomarkers were performed before and after administration of autologous dendritic cells. Results The results showed that before administration, the median PSV value was 47.1 ± 23.87 cm/s, which decreased to 27.85 ± 20.53 cm/s with a p-value of 0.044, and EDV increased from 13 ± 5.32 cm/s to 15.7 ± 12.55 cm/s with a p-value of 0.039. The female group showed a significant decrease in PSV with a p-value of 0.03 and a significant increase in EDV with a p-value of 0.044. The microalbuminuria group showed a significant decrease in PSV with a p-value of 0.011. Analysis of TGF β and MMP 9 showed before administration of autologous dendritic cells, each increase of one unit of MMP 9 increased TGF β by 13.112, and after administration, it became 7.622. Conclusion This study shows that the administration of dendritic cells can improve renal hemodynamics and, in the long term, is expected to reduce fibrosis in the kidney.