T cell mitochondrial function was used to assess the severity and exacerbation risk of coronary artery disease

Objective Exploring the Correlation between Mitochondrial Function of T Cells and the Severity of Coronary Artery Disease. Methods A total of 118 patients with coronary heart disease were divided into 32 cases in the ACS group and 25 cases in the stable angina pectoris (SAP) group. Meanwhile, 61 non-coronary heart disease patients who were hospitalized during the same period were selected as the control group. The expression levels of CD3 + T lymphocytes, CD4 + T lymphocytes and CD8 + T cells, CD4-MM, CD8-MM,CD4-MMP,CD8-MMP in the plasma of the three groups were detected by a flow cytometry instrument and the human lymphocyte mitochondrial function. Results In the SAP and ACS groups, CD4MMP and CD8MMP were significantly lower than those in the control group, while CD4MM was significantly higher than that in the control group(P<0.05).However, there were no differences in CD4MMP, CD8MMP, and CD4MM between the SAP group and the ACS group(P > 0.05). CD4MM in the STEMI group was higher than that in the UA/NSTEMI group. Conclusion In the peripheral blood of patients with coronary heart disease, the levels of CD4MMP and CD8MMP are significantly decreased, while CD4MM is significantly increased. These indicators can be used as predictive markers for the occurrence of coronary heart disease.