The Association Between Chronic Kidney Disease and Presbycusis: A Mediation Analysis of the Inflammatory Biomarker Neutrophil-Percentage-to-Albumin Ratio (NPAR)

This study assessed the association between Chronic Kidney Disease (CKD) and presbycusis and to investigate whether inflammatory neutrophil percentage-to-albumin ratio (NPAR) indicators influence this relationship.This study used data from the National Health and Nutrition Examination Surve and employed such as restricted cubic spline analysis, multiple logistic regression analyses and mediation analyses to explore these relationships.High-frequency Hearing Impairment(HI) was correlated with moderate CKD (OR = 3.25, 95% CI = 1.25–8.46, P  = 0.02). HI grades were correlated with moderate CKD [for slight HI, (OR = 5.13, 95% CI = 1.48–17.86, P  = 0.01); for moderate and severe HI, (OR = 4.68, 95% CI = 1.29–17.04, P  = 0.02)]. Mediation analysis revealed that NPAR had a 17.85% mediating effect on the association between moderate CKD and presbycusis.Moderate CKD was associated with high-frequency HI in the elderly and that NPAR had a significant mediating effect on this relationship.