Knowledge, Attitude and Perception of Sickle Cell Disease, on Premarital Genotype Screening, Among Undergraduate of Al-Hikmah University Ilorin. Nigeria.

Genetic compatibility needs to be carefully considered i n an effort to lessen the frequency of sickle cell disease (SCD), especially in Nigeria and other African where the disease has a high burden with morbidity and mortality. It has been demonstrated that knowledge of premarital genotype screening PMS, educates individuals about SCD. The descriptive study was aimed to assess the knowledge, attitude and perception of SCD on PMS on selected university student participants. The population for the study are undergraduates, the multi-stage sampling technique was used in sample selection of the 341 respondents, and data was collected using a self-administered questionnaire. Findings indicate 88.3% fell within age range of 18–25 years, 70.1% were female and single, representing 93.5% and a significant proportion. 76% have heard understand SCD and are generally familiar with the complications of SCD. Only 56% have good knowledge of PMS as the cheapest prevention, While 63% don’t know about premarital sickle cell counselling. Only 56% knew their Hemoglobin genotype, however 12% knew Hemoglobin genotype of their fiancés and 69% are of the opinion of terminate relationship if the genotype result is incompatible. 68% support mandatory PMS and the establishment of laws prohibiting marriage in cases of PMS incompatibility. The statistical analysis given that P-value is 0.000, which is < alpha level of 0.05, therefore null hypothesis rejected, It was concluded that knowledge of genetic composition and the potential threat of SCD was robust, mandatory PMS with better counselling strategies, laws to regulate genetic diseases and willingness in advocating PMS to intending couples was confirmed. Recommendations, carrier identification and genetic counselling enlightenment on SCD and PMS testing through mass media and screening centers should be made by the government and religious institutions