Synthesis and characterization  of Substituted Schiff Base from Benzene-1,4-Diamine: Study of Biological Activity and Corrosion Inhibitor Effect

This work includes a simple condensation reaction between aromatic amine " 2,5-dimethyl-benzene-1,4-diamine" or "2,3,5,6-tetramethyl-benzene-1,4-diamine with a carbonyl compound (pyridine-2-carboxaldehyde") to produce a new ligand. The produced ligands (L1a, L2a) were underwent to reduction reactions using (NaBH4) at room temperature to produce the new ligands" 2,5-dimethyl-N,N'-bis-pyridin-2-ylmethyl-benzene-1,4-diamine" (L1b) and "2,3,5,6-tetramethyl-N,N'-bis-pyridin-2-ylmethyl-benzene-1,4-diamine "(L2b). All ligands (L1a-L2b) are characterized by 1H-13C NMR, FT.IR, mass spectrometry, and elemental microanalysis. The ligands (L1b, L2b) effectiveness was examined as corrosion inhibitors and gave good results. In another application, activity of ligands was studied against two bacterial types E. coli (Gram-) and Staph. (Gram+) in comparison with the drug used Chloramphenicol. The ligands (L1a and L1b) showed a highest inhibition, but the ligands) L2a andL2b (did not show any inhibition effect at 25and50 Conc.(μg/ml)