Dissecting the Role of Cellular Senescence in Meningioma Recurrence: Integrative Bioinformatics and Elastic Network Modeling

Background Cellular senescence is intimately tied to tumorigenesis and progression, yet its exploration in meningiomas remains inadequate. In this study, we aim to unravel the role of cellular senescence-associated genes (CSA-genes) in meningioma recurrence and identify potential diagnostic markers and therapeutic targets. Methods We analyzed GSE136661 and GSE173825 datasets to identify CSA-signature genes through differential expression analysis, weighted gene co-expression network analysis, protein-protein interaction network construction, and elastic net regression modeling. Functional enrichment, immune cell infiltration using CIBERSORT, and transcription factor prediction were performed. Potential drugs were screened using Enrichr database. Results CDK1, FOXM1, MYBL2, and BIRC5 emerged as key CSA-genes related to cell cycle and DNA damage. Recurrent meningiomas showed immune heterogeneity, with CSA-genes correlating with immune infiltration and checkpoint molecules. E2F1 was predicted as a regulator. Dasatinib and Rapamycin showed promising anti-meningioma potential. Conclusion Our findings highlight crucial genes and pathways in meningioma recurrence, introducing novel therapeutic candidates. These findings pave new avenues for further elucidating meningioma recurrence mechanisms and developing innovative treatments.