Analysis of COMMD10 Expression Patterns in Gliomas and Its Impact on Immune Cell Infiltration and Patient Prognosis

The human COMM domain protein 10(COMMD10), is known to have a potential biomarker associated with diverse cancers, but its prognostic value in gliomas, association with immune cell infiltration, and oncogenic mechanisms remain unclear. This study analyzed TCGA and GTEx databases, combined with bioinformatics methods such as Kaplan-Meier survival analysis, ROC curves, and GO/KEGG enrichment, to explore its expression characteristics, clinicopathological correlations, and prognostic significance. Results showed that COMMD10 is significantly overexpressed in gliomas, whereas this overexpression positively correlates with tumor invasiveness and poor prognosis of glioblastomas, and associated with activation of immune response pathways and enhanced immune cell infiltration. In vitro experiments confirmed that knocking down COMMD10 can inhibit GBM cell proliferation and promote DNA damage accumulation. In conclusion, COMMD10 has a potential role as an independent biomarker, as well as an indicator manifesting the infiltration of different sorts of immune cells among glioblastomas, and targeting COMMD10 may improve the efficacy of GBM immunotherapy.