Association of PPAR γ and TRHR Gene Variations, with Metabolic Factors in Diabetic and Obesity Individuals in the Population; An Investigation Study

Obesity, a global pandemic with multiple causes, significantly impacts physical health. Factors such as genetics, ethnicity, physical inactivity, excessive calorie intake, stress, and socioeconomic status contribute to the development of metabolic disorders like diabetes, cardiovascular disease, and metabolic syndrome. This study was designed to examine the genotype differences of PPAR γ (rs1801282) and TRHR (rs16892496) polymorphisms known to be associated with obesity in different populations and to determine the role of these variants in the etiology of obesity in the Turkish population. Genotyping of rs1801282 and rs16892496 polymorphisms were conducted by using the Real Time-PCR in study group which consists of 160 patients with diabetes and obesity and 79 healty controls. Upon analyzing the relationship between genotypes and metabolic parameters, individuals with GG genotype showed significantly different BMI values compared to individuals with CC and CG genotypes in the non-diabetic obese group, indicating the possible effect of GG genotype on obesity severity (p = 0,008). In the control group individuals carrying C allele exhibited levels of HDL cholesterol compared to G allele carriers with statistical significance observed (p = 0.034). Analyzing the relationship between genotypes and metabolic parameters we observed that BMI values of A allele carriers in the control group were notably lower than those of C allele carriers with a difference (p = 0.026). These results underscore the significance of influences in obesity and diabetes pathogenesis indicating roles for PPAR γ and TRHR genes in these conditions development. Nonetheless further research, with more diverse samples is necessary to comprehend these connections.