The diagnostic value of serum C-reactive protein/high-density lipoprotein in microvascular angina

Objective This study aimed to explore the relation ship between the serum ratio of C-reactive protein (CRP) to high density lip opro tein cholesterol (HDL-C) with microvascular angina(MVA).It also aimed to evaluate the predictive value of serum CRP /HDL-C in relation to MVA. Methods The observation group consisted of 70 patients diagnosed with MVA ,while the control group included 68 patients with normal or minimal (< 50%) stenosis on coronary angiography, negative ECG exercise test and normal coronary blood flow randomly selected using a random number table method.Serum CRP,HCY,HDL-C and other relevant parameters were measured in both groups, with CRP /HDL-C calculated.Logistic regression analysis, and receiver operating characteristic (ROC) curve analysis were performed to identify independent risk factors for microvascular angina. Results CRP/HDL-C levels were significantly elevated in MVA patients with statistical significance (P < 0.001).The parameterswas identified as independent risk factor for predicting MVA occurrence.The results of ROC analysis indicated that CRP /HDL-C showed high predictive value for diagnosing MVA .The CRP/HDL-C had a higher area under the curve (AUC) for diagnosing microvascular angina compared to individual parameters ,with a statisticallysignificantdifference(P<0.05). Conclusions Elevated CRP /HDL-C levels can serve as positive predictors for diagnosing MVA.The parameters can enhance diagnostic accuracy and aid in the early identification of MVA patients..