Association of Systemic Immune Inflammation Index and System Inflammation Response Index with Cardiovascular Disease among prediabetes and diabetes

We aimed to explore the association of the systemic immune inflammation (SII) index and system inflammation response index (SIRI) with CVD among prediabetes and diabetes. The cross-sectional study included 4534 participants with prediabetes and diabetes from the National Health and Nutrition Examination Survey (NHANES) 2015–2018. Multivariate logistic regression analysis was used to assess the association of SII and SIRI with CVD. Restricted cubic spline (RCS) model was used to examine the dose-response relationships between SII, SIRI, and CVD. Among 4,534 individuals with prediabetes and diabetes, the prevalence of CVD was 16.6%, with 19.4% in males and 14.0% in females. SII (OR: 1.27, 95%CI: 1.04–1.56) and SIRI (OR: 1.38, 95%CI: 1.09–1.76) were positively associated with CVD among prediabetes and diabetes. Among prediabetes, SIRI was positively associated with CVD (OR: 1.32, 95%CI: 1.03–1.70). Among diabetes, there was a similar finding that SIRI was positively associated with CVD (OR: 1.43, 95%CI: 1.04–1.96). The dose-responses relationship of SIRI with CVD was significantly nonlinear ( P for nonlinear < 0.001). SIRI index may be an important biomarker in people with diabetes and prediabetes. Therefore, we recommended long-term monitoring of the SII index and SIRI in these vulnerable individuals.