SARS-CoV-2 Phylointeractomics Reveal Functional Evolution of Its Variants Across Susceptible Human Organs

  1. Xu Li
  2. Peihan Wu
  3. Danqi Bao
  4. Zhihao Guo
  5. Hua Jiang
  6. Yue Sui
  7. Weixiang Bian
  8. Shuai Wang
  9. Fa Zhang
  10. Jianbo Wu
  11. Yunkai Zhu
  12. Jiaying He
  13. Weiyu Jiang
  14. Xiya Deng
  15. Tingting Zheng
  16. Rong Zhang
  17. Peihui Wang
  18. Qiao Wang
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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mainly infects the tissues of the human respiratory, nervous, digestive and urinary systems. Here, we conducted an integrated study of the viral–host protein‒protein interactions between 29 wildtype SARS-CoV-2 proteins and 15 SARS-CoV-2 variant S proteins and human lung-, bronchus-, neuron-, liver- and kidney-derived cells, identified 745,163 viral–host protein‒protein interactions and established phylointeractomics of SARS-CoV-2 variants across susceptible human organs. We highlighted interacting proteins involved in the function evolution of viral proteins under different cellular contexts, and identified several as potential drug targets for treating related complications and sequalae. The results reveal how various viral proteins contribute to the infection, replication and immune evasion by interacting with general and cell type-specific host proteins.

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  1. Version published to 10.21203/rs.3.rs-4254091/v1 on Research Square