A case analysis of intracranial infection of Porphyromonas gingivalis

OBJECTIVE A case of intracranial infection caused by Porphyromonas gingivalis was analyzed to provide evidence for clinical treatment. METHODS In one patient with intracranial infection, the results of multiple blood culture and cerebrospinal fluid culture were negative, and no pathogenic bacteria were found. Porphyromonas gingivalis in cerebrospinal fluid was determined by macrogene detection method, and the empirical selection of vancomycin combined with ceftriaxone anti-infection treatment was converted to metronidazole target treatment. RESULTS After 4 weeks of treatment, the patients recovered completely, and the laboratory examination indexes were normal. The results of brain CT and cerebrospinal fluid metagene test were negative. CONCLUSION For intracranial infection caused by rare microorganisms, under the premise of negative results of classical bacterial culture, advanced macrogene sequencing method can be used to determine pathogens, providing rapid and accurate detection results for clinical treatment. Subject classification codes: include these here if the journal requires them