Protective Effects of Laktera Nature Probiotic in Experimentally-Induced Gastric Ulcers in Rats

Probiotics are live microorganisms that, when administered in adequate amounts, confer health benefits to the host. The present study aimed to evaluate the protective effects of a probiotic against experimentally induced gastric ulcers in rats. Male Wistar rats were allocated into five groups (n = 6 per group): Control, Model (indomethacin-induced ulcers, IND), Positive control (IND + famotidine), IND + Laktera Nature (LN) probiotic (800 mg/kg), and IND + LN probiotic (1600 mg/kg). The study duration was 14 days. On day 15, rats in groups 2–5 received 1 ml of indomethacin (40 mg/kg) orally. All rats were euthanized four hours later via cervical dislocation under diethyl ether anesthesia. LN probiotics have demonstrated dose-dependent protection against indomethacin-induced gastric ulcers, as assessed by both macroscopic and microscopic evaluation. Therefore, LN probiotics may represent a valuable adjunctive strategy in the management of gastric ulcers.