Growth, Aging and (Epi)Genetics in Light of Piezo2 and Quantum (Gravity) Theory

The current manuscript is meant to introduce how piezo2 channelopathy may play a critical role in (epi)genetics, when it comes to development, growth and aging initiation from a neurocentric view. Accordingly, it demonstrates how the principality of excitatory Piezo2 ion channel may not only reflected in Piezo cross-frequency coupling, transcription activation, ultradian event sensing and modulation, but might also fine-modulates emergent entropic force from gravity and (epi)genetics, hence underscoring its principality not only in proprioception. The implicated Piezo ion channels, especially Piezo2, have cellular, inter-cellular, compartmental and systemic effect through a Piezo system, however the underlying backbone ultrafast (glutamatergic proprioceptive Piezo2) system may carry the principality. Syndecans as co-functioning accessory ligand of Piezo2 may serve the non-linear dynamics of the ultrafast non-linear time-delay system in order to quantum tunnel/synchronize protons in an ultrafast fashion into the suggested anticipatory coupled hippocampal chaotic system. The co-function of the intrinsically disordered intracellular domain of Piezo2 and the intrinsically disordered ectodomain of syndecans may posit the critical structure in this proposed ultrafast non-linear dynamics that may be impaired due to Piezo2 channeloapthy, leading to altered response to postural perturbations, consequently might cause an increased the risk of non-contact injuries. Proton affinity switch on proprioceptive glutamatergic terminals may not only induce acquired Piezo2 channeloapthy and resultant switch to glutamate-based signaling, but may miswire protons as well through the lipoxygenase pathway. This proton miswiring may also inhibit fine-regulation of excitatory AMPA information processing in neuronal synapsis. After all, acquired Piezo2 channelopathy may posit such an initiatingcritical primary damage that impacts development, growth and aging through (epi)genetics, however quantum (gravity) theory is needed for translation.