First Total Synthesis of Pestasulfamides A and B Through Iminoketene Dimerization of Anthranilic Acid in One-Pot Manner
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Pestasulfamides A and B are phenylbenzene-sulfonamides with an eight-membered dilactam, produced by mangrove endophytic fungus Pestalotiopsis sp. HNY36-1D. Herin, the first total synthesis of pestasulfamides A and B was achieved through one-pot protocol. The key step features an iminoketene dimeriazation of anthranilic acid triggered by a sulfonylation in a pyridine/THF system.