A Novel PCF SPR Biosensor Using TiO₂ and Gold Coating for Carcinoma Cell Detection

A responsive dual-core surface plasmon resonance-based photonic crystal fiber DCSPRPCF biosensor has been present in this study, which has been designed for the early and true detection of carcinoma. It is capable of identifying different types of carcinoma cells such as MDAnderson - Metastatic Breast –231(MDA-MB-231), Michigan Cancer Founda-tion-7(MCF-7), Pheochromocytoma (PC12), and Jurkat Cells. It incorporates a titanium dioxide intermediate layer, thereby improving the joining between the silica fiber and the Au layer at the surface of the plasmonic material, resulting in excellent performance. Carcinoma will be detected by calculating the variation in resonance frequency due to the distinction in ReI among the nutritious and Carcinogenic cells by using the Frequency Investigation method. For MDA-MB-231 cells, the sensor achieves peak responsiveness of 16428.54 nm/RIU when the refractive index changes by 0.014. In addition, more Figure of Merit, with a peak utility of 74.29 RIU⁻¹ for PC12 cell detection, guarantees the reliability and accuracy of this sensor.