Innovative Strategies in Therapeutic Delivery Including Liposomes Nanoparticles Fast Dissolving Dosage Forms and Effervescent Formulations

The sustained development of science in drug delivery has transformed contemporary therapeutics towards targeted, controlled and patient-centred therapy. In this review, the authors analyze the development and incorporation of liposomal, nanoparticulate, and oral fast-dissolving systems as new drug delivery systems. The paper starts with the rationale and strategic principles of the controlled delivery, then proceeds to discuss vesicular delivery vehicles (liposomes, proniosomes, and niosomes) and their structural benefits and pharmaceutical importance. Both polymeric and inorganic nanoparticles are also discussed due to their ability to improve bioavailability, oral peptide delivery, and effusive dispensation of drugs. Solid lipid system in the form of Solid lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) provide even greater stability and biocompatibility to support sustained and localized therapeutic effects. In addition, the introduction of dissolvable, effervescent and chewable dosages, improve patient compliance and guarantee the fast onset of a pharmacological effect, especially in patients with swallowing problems. The combination of formulation technology and nanomedicine is manifested through controlled and sustained-release approaches, which are combined with vesicular nanocarriers. The final part of the review is dealing with the translational issues, regulatory approaches, and future opportunities of incorporating nanocarrier-based therapeutics in clinical practice. Taken together, these inventions represent a paradigm shift of more effective, safer and more personalized pharmaceutical treatment that will be in line with the trends in precision medicine around the world.