Bioactivity, Storage Stability, and <em>In Silico</em> Insights of Collagen-Derived Peptides from Jellyfish (<em>Stomolophus</em> sp. 2) Mesoglea
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Jellyfish, a promising source of bioactive compounds, have attracted the attention of the biotechnology sector. This research has explored the antioxidant and antimutagenic properties, genotoxicity, and stability of peptides derived from blue cannon jellyfish (Stomolophus sp. 2) collagen hydrolysates (JCH) as potential food supplements. JCH was fractionated into three parts: F1 (molecular weight > 10 kDa), F2 (10 kDa > molecular weight > 3 kDa), and F3 (molecular weight < 3 kDa) using ultrafiltration. Notably, F3 exhibited the highest antioxidant and antimutagenic activities while remaining non-genotoxic, supporting its safety for potential applications. The function of JCH and its fractions to quench free radicals persisted even after three months at 4°C. In addition, in silico analysis revealed 15 unique peptides in Stomolophus sp. 2 collagens, ten of which showed particularly promising bioactive potential. Peptides from Stomolophus sp. 2, with molecular weight under three kDa, exhibit remarkable bioactivity, holding great promise for future research into bioactive food supplements.