Anti-Aging Properties of Ingredients Available in Zeitgain Cream

Skin aging is a multifactorial biological process influenced by intrinsic factors such as genetics and the natural chronological ageing process, as well as extrinsic environmental factors, including oxidative stress, UV radiation and pollution. Due to these, the structural and functional deterioration of skin occurs resulting in manifestations such as wrinkles, loss of elasticity and pigmentations. Anti-aging cosmeceuticals are widely recognised for their ability to mitigate these manifestations. However, synthetic formulations such as retinoid which are commonly used lead to adverse reactions and undesirable effects such as photosensitivity. With the increasing demand for safer and natural formulations, Zeitgain creams were developed in Sri Lanka, composed with natural bioactive ingredients such as virgin coconut oil, Aloe vera, pomegranate extract, cucumber seed oil, saffron, Garcinia indica (kokum), vitamin E, vitamin C, hyaluronic acid, niacinamide, and zinc PCA which have demonstrated significant antioxidant, anti-inflammatory and collagen preserving properties. These ingredients can scavenge reactive oxygen species, stimulate collagen and hyaluronic acid synthesis, inhibit matrix metalloproteinases and modulate inflammatory pathways, thereby improving skin hydration, barrier functions and elasticity. Zeitgain creams use functional excipients including glycerine, cetyl alcohol, stearic acid, glyceryl monostearate and carbopol, which contribute to skin hydration, emulsion stability and active ingredient delivery. Notably, safety considerations generally recognise these ingredients as safe. This review evaluates the scientific evidence related to bioactive compounds in Zeitgain creams, focusing on natural and synthetic components.