Efficacy of an Oral Synergistic Combination of Active Ingredients with Photoprotective, Antiaging and Pigmentation Control Activity in Asian Women

(1) Background: Skin hyperpigmentation as well as other changes (loss of firmness, elasticity, wrinkles), are signs that progressively deteriorate the skin appearance. The objective of the study was to assess whether the tested product is effective and safe in terms of improving the signs of skin aging. (2) Methods: a clinical randomized, placebo-controlled and double-blind study was car-ried out on 40 healthy female subjects who took two capsules/day for 12 weeks. One arm of the study (26 subjects) received the active product, while the other arm (14 patients) received the placebo. The capsules of the test product (Heliocare® Luminance) contain actives such as Polypodium leucotomos extract, glutathione, Rosemary extract, Ni-acinamide and Magsenium stearate. Instrumental evaluations were performed to assess the pigmentation intensity, skin brightness, skin elasticity and firmness, deep wrinkles, skin hydration and transepidermal water loss at Week 0, Week 4, Week 8 and Week 12. Subject questionnaire about efficacy of the test product and skin safety assessment were conducted at Week 4, Week 8 and Week 12. Side effects were evaluated at different time points. (3) Results: After 12 weeks of study, it was demonstrated that oral intake of Heliocare® Luminance improved hyperpigmentation, skin elasticity and firmness, deep wrinkles, skin barrier function and skin hydration, reaching statistical differences vs placebo. (4) Conclusions: the product with synergistic combination prevents and improves hyperpigmentation, aging signs and skin damages induced by solar radiation.