Insights on the Management of Bacterial Infections and Quorum Sensing in the Context of Interkingdom Interactions

As pathogens refine their infection strategies via a complex network of molecular structures, we assert that investigating the existence of quorum sensing (QS) signals in bacteria and their impact on interkingdom signaling, as well as the evolutionary emergence of quorum quenching (QQ) mechanisms that enzymatically degrade QS signals, or the mechanisms that disrupt QS systems through quorum sensing inhibitors (QSI) that competitively bind to QS molecule receptors on bacterial cell surfaces, is essential for elucidating how naturally evolved mechanisms may adapt to combat human infections.