Negative Relationships Between the Intensity of Immunohistochemical Staining for USP13 and Factors Associated with the Progression of Prostatic Carcinoma

Purpose: For downregulating phosphate and tensin homolog deleted on chromosome 10, well-established tumor suppressor, requires the ubiquitin-proteasome system such as USP13. The aim of this study was to identify the relationships between the intensity of immunohistochemical staining for USP13 and factors associated with the progression of prostate carcinoma. Materials and methods: USP13 staining was scored for each histological cohort as either high, medium, low or negative in 242 prostate cancer tissues and 22 controls. Results: Higher UPS13 grades were exhibited by non-malignant tissues than prostate carcinoma. In comparison, lower USP13 grades were observed in 88.6% of the neoplastic regions (p < 0.001). No differences in PSA level, Gleason’s score, disease stage, involvement of either the seminal vesical or lymph nodes, surgical margin positivity, biochemical or clinical recurrence rates or overall survival statistics were found. No relationship was identified between USP13 immunohistochemical staining intensity and either biochemical recurrence free or overall survival following Cox proportional hazard modeling. The grade of USP immunohistochemical staining was associated, according to the Kaplan-Meier technique, with biochemical or clinical tumor recurrence, and overall survival. Conclusion: In tissue microarrays (TMAs) from patients with prostate carcinoma, USP13 immunohistochemical staining can be used to differentiate neoplastic tissue from non-malignant neighboring tissue regions.