Successful Use of Platelet-Rich FIbrin for the Healing of Residual Bone Cavity After Enucleation of Large Radicular Cyst: A Case Report

Background/Objectives: The choice of optimal method for the healing of residual bone cavities after enucleation of large radicular cysts is widely discussed. One of them may be using platelet-rich fibrin (PRF), which produce growth factors that stimulate reparative osteogenesis. We have described a case of successful use of PRF for the healing of residual bone cavity after enucleation of large maxillary radicular cyst. Methods: A 58-year-old female patient presented with a large maxillary radicular cyst. Cyst enucleation was performed, the residual bone cavity was filled with PRF clot, and the bone wound was completely covered with a mucoperiosteal flap. Results: One year after the operation, сone-beam computed tomography visualized the vague contours of the residual cavity filled with bone trabeculae, which had significantly decreased compared to the preoperative findings. Parietal bone regeneration was detected, while no signs of organotypicity were recorded in the center. Two years after the operation, сone-beam computed tomography showed complete filling of the residual cavity with bone tissue to the level of the teeth roots, with beginnings of vestibular cortical formation. Separate sections of the cortical bone layer on the vestibular side at the level of teeth 1.2 and 1.1 were in the process of repair. The functioning preserved teeth 1.3, 1.2, 1.1 and 2.1 were in stable condition. Conclusions: The use of PRF can contribute to successful healing of residual bone cavity after enucleation of large radicular cyst.